Prompt and correct diagnosis of hypophosphatasia (HPP) is crucial for being able to offer adequate care. For infants with undiagnosed hypophosphatasia, a delay in diagnosis may be life-threatening.

Diagnosis can be made more difficult by the fact that the various symptoms/forms of hypophosphatasia cannot be clearly distinguished, and the disease can resemble several other considerably more common diseases. The differential diagnoses are thus numerous, of which vitamin D deficiency and Osteogensis Imperfecta (OI) are two of the most common. This entails a risk that the patient may be given treatment for an incorrect diagnosis, with vitamin D, a calcium supplement or bisphosphonates. These treatments that can lead to worsening of HPP symptoms.

Mornet E. Best Pract Res Clin Rheum 2008; 22: 113-127.
Rockman-Greenberg C. Ped Endocrinol Rev 2013; 10 (Suppl 2): 380-388.
Whyte MP. Ann N Y Acad Sci 2010; 1192: 190-200.

SYMPTOMS AND CONDITIONS
ASSOCIATED WITH HYPOPHOSPHATASIA

COMMON SYMPTOMS AND CONDITIONS THAT
CAN BE CAUSED BY HYPOPHOSPHATASIA READ MORE

THE ALP CALCULATOR
– DIAGNOSTIC TOOL

LOW ALP ACTIVITY KEY TO DIAGNOSIS READ MORE


IMPORTANT DIFFERENTIAL DIAGNOSES

IMPORTANT DIFFERENTIAL 
DIAGNOSES/CONDITIONS READ MORE
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