Hypophosphatasia (HPP) is not just a skeletal disease; it is also a systemic disease

The consequences of low ALP activity and accumulation of ALP substrate can be life-threatening or lead to serious systemic complications. The systemic consequences of the disease result from changed bone metabolism that often affects the skeleton and/or teeth. Symptoms can also be neurological, respiratory, muscle-related, rheumatological and/or kidney-related.

Click here to access the diagnostic algorithm and to read more about common symptoms of hypophosphatasia.

Mornet E. Best Pract Res Clin Rheum 2008; 22: 113-127.
Mornet E et al. Ann Hum Genet 2011; 75: 439-445.
Rockman-Greenberg C. Ped Endocrinol Rev 2013; 10 (Suppl 2): 380-388.
Whyte MP. Ann N Y Acad Sci 2010; 1192: 190-200.

SYMPTOMS AND CONDITIONS
ASSOCIATED WITH HYPOPHOSPHATASIA

COMMON SYMPTOMS AND CONDITIONS THAT
CAN BE CAUSED BY HYPOPHOSPHATASIA READ MORE

THE ALP CALCULATOR
– DIAGNOSTIC TOOL

LOW ALP ACTIVITY KEY TO DIAGNOSIS READ MORE


IMPORTANT DIFFERENTIAL DIAGNOSES

IMPORTANT DIFFERENTIAL 
DIAGNOSES/CONDITIONS READ MORE
AlexionAlexion Pharma Nordics AB, Vasagatan 7, 111 20 Stockholm, Sweden. Copyright © 2017, Alexion Pharmaceuticals, Inc. All rights reserved. Sitemap